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- Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (7)

Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (7)Individual behavior of cardiac morphology indices was widespread (Fig 1): left ventricular mass did not change in four patients and increased in four patients, while in the remaining three patients it showed a reduction. A similar behavior was observed for the other morphologic indices. No relationship was observed between changes in left ventricular mass and the length of the period of treatment and the degree of blood pressure control. The average values of systolic function indices did not change significantly during the treatment with prazosin.

At the beginning of the study, the value of EF in all hypertensive patients was in the normal range (>55 percent) and after the treatment average value changed from 62^72±7.50 percent to 56.13 ±8.31 percent, the difference not being statistically significant. A similar behavior was also observed for PER, both as absolute values and as values corrected for the corresponding heart rate: average PER did not change significantly after the treatment and individual values showed both a decrease or an increase. Before treatment PER, PFR, and FFV6 were significantly lower and tPFR was significantly higher than normal controls’ values. The average values of the diastolic function indices worsened after the treatment with prazosin, even if the differences never reached statistical significance.

Figure-1

Figure 1. Individual values of cardiac morphology indexes before and after treatment with prazosin. PWt = posterior wall thickess; IVSt = interventricular septum thickness; CSAi = cross-sectional area index; and LVMi = left ventricular mass index.

July 10, 2013 Diastolic function
Tags: cardiac morphology diastolic function echocardiography prazosin