Flovent Inhaler

- Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (6)

Pearsons linear regression was used to test the relationship between blood pressure, left ventricular mass, and indices of systolic and diastolic function. Significance was established at the level of p<0.05 (two-tailed analysis).
Results
Average blood pressure values significantly decreased during the treatment with prazosin: systolic blood pressure from 163.54 ±17.80 mm Hg to 146.81 ±13.14 mm Hg (p<0.01), and diastolic blood pressure from 106.09 ±6.96 mm Hg to 92.90 ±8.93 mm Hg (p<0.01). Heart rate values increased slightly, but the difference was not statistically significant (from 73.73 ±9.73 to 85.73 ± 16.00). Average values of cardiac morphology before and after antihypertensive therapy are shown in Table 1. The measurements of the left ventricular systolic and diastolic filling indices in the hypertensive subjects at the beginning and at the end of the study are shown in Table 2, which also includes the mean values from a group of 16 normal subjects of our laboratory.
During the treatment with prazosin, interventricular septum and posterior wall thicknesses showed a trend toward reduction, but the differences did not reach statistical significance. Cross-sectional area and left ventricular mass were unchanged, as well as the other considered echocardiogr&phic parameters.

Table 1—Average Values (±1 SD) of Echocardiograpkic Measurements of Morphology in Hypertensive Subjects before and after Treatment with Prazosin

Indices Before Prazosin After Prazosin
IVSt, cm 1.02±0.19 0.95 ±0.20
PWt, cm 1.04 ±0.26 0.96 ±0.13
LVMi, g/m2 114.81 ±33.10 116.08 ±20.13
CSAi, cm2/m2 11.08±2.24 10.65 ±1.65
EDd, cm 4.74 ±0.56 5.00 ±0.48
ESd, cm 3.04 ±0.55 3.32 ±0.44
EDv, ml 106.43 ±31.22 119.40 ±25.46
ESv, ml 37.96 ±16.57 45.85 ±14.13
RDWt 0.46 ±0.18 0.44 ±0.18

Table 2—Average Values (±1 SD) of Scintigraphic Measurements of Systolic and Diastolic Function in Hypertensive Subjects, before and after Treatment with Prazosin and in a Control Group of 16 Normal Subjects

Indices ControlGroup BeforePrazosin AfterPrazosin
EF, % 69.73 ±6.36 62.72 ±7.50t 56.13 ±8.31$
PER, EDv/s 3.34±0.48 2.86 ±0.29$ 2.60 ±0.64$
PFR, EDv/s 3.21 ±0.54 2.30 ±0.42* 2.14 ±0.49$
FF»/i, % 63.66 ±9.23 32.70 ±8.05$ 30.29 ±9.89$
tPFR, ms 134.87 ±20.9 189.72 ±34.16$ 192.00 ±53.19$
July 7, 2013 Diastolic function
Tags: cardiac morphology diastolic function echocardiography prazosin