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- Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (5)

Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (5)Using threshold and second-derivative technique, the left ventricular regions of interest were obtained. The time-activity curves were generated using these regions applied to the raw data and subtracting the background values. The ejection fractions were calculated from the time-activity curve in the usual manner (the end-diastolic count minus the end-systolic count divided by the end-diastolic count minus the background count). The rates and the other diastolic indices were obtained by the Fourier analysis (fourth harmonic) of the time-activity curves. The first derivative of the fitted curves provided the PFR (positive derivative) and PER (negative derivative), expressed in units of end-diastolic volume/s; the tPFR was measured from end-systole to the time at which the PFR occurred. The FF l/i is the fraction between the increase in count obtained at the first third of diastole and the total stroke count, expressed as a percentage. In our laboratory, intraobserver variability in the measurement of cardiac function has been established at less than 10 percent.
Statistical Analysis
Data are presented as means ± 1 SD. Paired Students t test was used to evaluate the effect of the antihypertensive therapy in the hypertensive patients. Unpaired Students t test was used to compare patients and control subjects.

July 5, 2013 Diastolic function
Tags: cardiac morphology diastolic function echocardiography prazosin