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- Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (12)

The reasons for this individual variability are not clear and it might be hypothesized that age, sex, duration of hypertension, individual genetic background, and neurohumoral influences can play an important role in affecting left ventricular mass under the same condition of blood pressure control.
It is known that the effect of blood pressure normalization on left ventricular mass occurs after a period of treatment whose length is variable according to the class of drugs used. Thus, it might be supposed that prazosin needs a longer time to produce an echocardiographically documentable effect. Nevertheless, no association has been demonstrated between left ventricular mass changes and follow-up length in our patients, as we observed for diastolic function. Even in those subjects treated for more than 12 months, a reduction of left ventricular mass or an improvement of left ventricular filling did not occur.
In conclusion, our study shows that long-term treatment with a j -adrenoreceptor antagonist does not produce relevant changes with regard to the cardiac consequences of pressure overload, ie, diastolic abnormality and increase of left ventricular mass, even if a significant and sustained blood pressure reduction is obtained. Perhaps it might be thought that only long-lasting treatments or drugs that specifically act on anatomic, metabolic, or neurohumoral factors can produce an improvement of the diastolic function.

July 23, 2013 Diastolic function
Tags: cardiac morphology diastolic function echocardiography prazosin