Flovent Inhaler

- Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (11)

Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (11)Furthermore, our results suggest that drugs which decrease blood pressure by means of o^-receptor blockade do not considerably counteract the impairment of diastolic function induced by these factors.
Cardiac Morphology
The otj-adrenoreceptor antagonists should not have a direct effect on left ventricular mass, but few studies evaluated this effect on humans and conflicting results were reported. After long-term treatment with prazosin, we have not observed changes of average values of left ventricular mass. Also, in the six patients whose blood pressure was well controlled for at least six months, left ventricular mass changes were not homogeneous: it was reduced only in two, while it was unchanged or even increased in tho┬že remaining. Therefore, these changes cannot be related to these behavior of blood pressure during the treatment period. We might speculate that in hypertension there is a variability of individual response of left ventricular mass to treatment, perhaps unrelated to blood pressure control.

July 20, 2013 Diastolic function
Tags: cardiac morphology diastolic function echocardiography prazosin