Flovent Inhaler

- Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (10)

However, only some of these factors have been thoroughly investigated, and therefore not all the mechanisms of derangement of early diastolic function have been clarified so far.
Most of the dynamic factors we were able to measure or estimate in this study were normal before the treatment and did not change after the treatment: systolic function indices, end-diastolic left ventricular dimensions and volumes (as indices of preload), and heart rate (as index of sympathetic drive to the heart). Dynamic exercise test and regional contractility (examined both with echocardiography and radionuclide techniques) were normal in all patients, both at the beginning and at the end of the study: we may therefore argue that the coronary blood flow was not significantly compromised in these patients. Afterload was decreased by the blood pressure reduction obtained with the treatment.
Despite the normality of these dynamic factors that can influence diastole, the diastolic (unction of our patients was impaired at the beginning of the study and did not show a homogeneous trend to improvement after treatment.
We may suppose, therefore, that other factors, mainly affecting muscle stiffness (ie, collagen content and cardiac myosin isozyme patterns) and/or intracellular calcium metabolism are to be considered responsible for the observed alterations of relaxation and early filling in our patients.

July 18, 2013 Diastolic function
Tags: cardiac morphology diastolic function echocardiography prazosin