Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (2)

Methods
Cases
The study population consisted of 11 patients (eight male, three female; mean age, 43.8 years) with mild to moderate essential hypertension in World Health Organization (WHO) stages 1 or 2. Patients showing clinical or instrumental evidence of ischemic heart disease, heart failure, or other cardiac disease were excluded. No patient had ever taken any kind of antihypertensive treatment.

Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (1)

Effects of Long-term Treatment with Prazosin on Left Ventricular Diastolic Function in Mild to Moderate Hypertension (1)In the natural history of hypertension, abnormalities of the diastolic performance of the left ventricle are an early manifestation of cardiac involvement, often preceding the development of left ventricular hypertrophy. Previous studies have shown that only some classes of antihypertensive agents are able to reduce left ventricular mass, control of high blood pressure being equal. It has not yet been established if blood pressure control leads to an improvement in left ventricular filling or if, also in this case, the improvement is related to the kind of antihypertensive drug used.